Drug treatment stopped transmission of HIV in gay couples, study finds

A European study of nearly 1,000 gay male couples who had sex without condoms where one partner had HIV and was taking antiretroviral drugs to suppress it has found the treatment can prevent sexual transmission of the virus.

After eight years of follow-up of the so-called serodifferent couples, the study found no cases at all of HIV transmission within couples.

The study proves, the researchers said, that using antiretroviral therapy (ART) to suppress HIV to undetectable levels also means it cannot be passed on via sex.

"Our findings provide conclusive evidence for gay men that the risk of HIV transmission with suppressive ART is zero," said Alison Rodger, a professor at University College London who co-led the research.

She said this "powerful message" could help end the HIV pandemic by preventing the virus' transmission in high-risk populations. In this study alone, for example, the researchers estimate that the suppressive antiretrovial treatment prevented around 472 HIV transmissions during the eight years.

The study was published in theLancet medical journal on Thursday.Its findings add to an earlier phase of the study which looked at HIV transmission risk for serodifferent heterosexual couples who also did not use condoms. It also found zero risk.

While 15 of the men among the 972 gay couples in this phase did become infected with HIV during the eight years of follow-up, genetic testing showed their infections were with strains of HIV acquired from another sexual partner.

The new findings aren't surprising but are great news nonetheless, said Dr. Darrell Tan,an infectious diseases physician at St. Michael's Hospital in Toronto. He'sprescribed and studied suppressive antiretrovial treatment, as well aspre-exposure prophylaxis (PrEP) medication takenby an HIV negative partner to prevent transmission from happening should they be exposed to the virus.

Butantiretroviral therapy andPrEPis expensive and access is uneven across Canada, Tan said.

"The data are so compelling there's not only direct clinical benefits, there's direct preventative benefits as well," Tan said. "We need to have universal access."

The cost ofantiretroviral therapy andPrEPas well as stigma of HIV might explain why every year in Canada about 2,400 new cases are reported.

Talking about putting people onantiretroviralmedications is one thing, but finding them, ensuring they're tested, starting treatment and stayingon it is another, saidDr. Isaac Bogoch,an infectious disease physician at Toronto General Hospital.

"This is often referred to as the cascade of care. And we know that a lot of people who are infected with HIV might be representative of more marginalizedpopulations," Bogoch said. "Some of these individuals might not have had the best interactions with society or with health care. Some groups that are disproportionately affected with HIV might have concombinant (associated with)mental health issues and these all need to be addressed."

Since the start of the AIDS epidemic in the 1980s, more than 77 million people have become infected with HIV worldwide. Almost half of them, 35.4 million, have died of AIDS-related illness.

Rachel Baggaley, the World Health Organization's co-ordinatorfor HIV prevention and testing, said this latest study "adds tothe clear and consistent evidence" that HIV transmission tosexual partners does not occur when someone with HIV is onantiretroviral therapy (ART) and their virus is suppressed.

"Increasing access to HIV testing [and]ART ... remainscritical for individuals and is central to the HIV public health
response," she said.

Global health experts say the fight against HIV is at a precarious point, with the annual number of AIDS deaths falling and the number of people getting antiretroviral treatment rising, while the number of new infections is stubbornly high at around 1.8 million new cases peryear.