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Sean Parker sets up $250 M US cancer immunotherapy collaboration

A $250 million US grant from Silicon Valley billionaire Sean Parker, announced on Wednesday, aims to speed development of more effective cancer treatments by fostering collaboration among leading researchers in the field.

Project alleviates need for scientists to secure grants

Sean Parker's institute aims to ensure members can easily share cancer research discoveries and tools. (Nano Visser/Parker Institute/Associated Press)
A $250 million US grant from SiliconValley billionaire Sean Parker, announced on Wednesday, aims tospeed development of more effective cancer treatments byfostering collaboration among leading researchers in the field.

The Parker Institute for Cancer Immunotherapy will includeover 40 laboratories and more than 300 researchers from six keycancer centres: New York's Memorial Sloan Kettering, StanfordMedicine, the University of California, Los Angeles, theUniversity of California, San Francisco, Houston's University ofTexas MD Anderson and the University of Pennsylvania inPhiladelphia.

"Any breakthrough made at one center is immediatelyavailable to another center without any kind of IP (intellectual
property) entanglements or bureaucracy," Parker, the co-founderof music-sharing website Napster and the first president ofFacebook, told Reuters in an interview.

The institute will focus on the emerging field of cancerimmunotherapy, which harnesses the body's immune system to fightcancer cells.

Recently approved drugs such as Yervoy and Opdivo fromBristol Myers Squibb Co and Merck & Co Inc's Keytruda have helped some patients sustain remission. But thosefirst-generation therapies do not work for everyone, and
scientists are trying to understand how to make them moreeffective.

"Very little progress has been made over the last severaldecades," Parker said, referring to cancer drug research.

"Average life expectancy has only increased three to six monthswith some of these drugs that cost billions to develop."

3 key research areas

The institute has identified three key areas of research modifying a patient's own immune system T-cells to target a
tumour; studying ways to boost patient response to currentimmunotherapy drugs; and research to identify other novel
targets to attack a tumour.

Parker said the current system of cancer drug developmentdiscouraged the kinds of risk-taking that could lead to a majorbreakthrough.

The new institute "is paradigm shifting," said Dr. JeddWolchok, chief of the melanoma and immunotherapeutics unit atMemorial Sloan Kettering Cancer Center.

He said it would alleviate the need for scientists to securegrants, which he said took up at least 30 per cent of his time,foster collaboration among accomplished scientists and provideaccess to the newest information processing and data technology.

"I have no doubt this will allow us to make progress, and tomake it much more quickly," Wolchok said.

The Parker Institute aims to ensure members can easily shareresearch discoveries and tools, as well as jointly conductclinical trials with standardized data collection andoperations.

Parker said the aim was to maximize the return on investmentby holding off on licensing deals until later in the researchprocess, or even after a drug has been approved by regulators.

Any profits would be funneled back into the institute.

Patented discoveries made by the cancer center researcherswill be shared 50-50 with the institute. A committee withmembers from each cancer center as well as representatives ofthe Parker Institute will review potential licensing deals.

Jeff Bluestone, a professor at UCSF and an early researcherof immunotherapy, was appointed president of the Parker
Institute.

Parker credited his late friend Laura Ziskin, a Hollywoodproducer known for such films as "Pretty Woman" and founder ofStand Up To Cancer, with raising his awareness of the need tooverhaul cancer research. She died of the disease in 2011.

"Losing Laura transformed me," he said.