'You must be very careful': Common questions about CBD health claims for pain and other conditions answered

Cannabidiol, or CBD oil, is promoted for a wide range of medical conditions. Recently, a review for doctors weighedthe science behind the claims.

The Clinicians' Guide to Cannabidiol and Hemp Oilswas published earlier this month in the journal Mayo Clinic Proceedings.

CBD is a compound found in the cannabis plant. It is not intoxicating, Health Canada said.

As of October 2018, the sale of dried cannabis, fresh cannabis, cannabis oil, cannabis plants and cannabis seeds are permitted under thethe Cannabis Act.

As consumer interest in CBD grows ahead of the Oct. 17 legalization of cannabis edibles,extracts and topicals,here's a primer to answer common questions about itshealth claims for seizures, pain and other conditions.

What is CBD approved to treat?

Epidiolex, a purified form of plant-based CBD, is the only CBD-related treatment approved by the U.S. Food and Drug Administration (FDA). It is used to treat severe forms of epilepsy.Epidiolexisn't listed in Health Canada's database of medications approved for use in this country.

Health Canada assigns a drug identification number (DIN)toall drug products evaluated and authorized for sale in this country. To qualify, a drug manufacturer needs to provide information including dosing, strength and how it's taken.

"Currently, there are two cannabis-related drugs that have a DIN and are authorized for sale in Canada," a spokespersonfor Health Canada said in an email.

Nabilone,a synthetictetrahydrocannabinol, or THC,product is approved to treatnausea. THC isthe main psychoactive component in cannabis that gives users a high.

The other drug with a DIN is Sativex, which is manufactured from whole botanical extracts and contains THC and CBD, according to Health Canada.Sativexis added totreatments aimed at relievingspasticityin adultswith multiple sclerosis. Spasticity is a muscle-control disorder.

No CBD-specific product hasa DIN.

As well, no other "cannabis-related drug (including fresh or dried marijuana or cannabis oil) has been approved to be marketed as a drug for therapeutic use and sale in Canada," Health Canada said.

What is CBD commonly used for?

There are anecdotal reports from usersof CBD helping with certain types of pain, such as nerve-related back pain.

"Chronic pain management continues to challenge patients and physicians alike, and investigation into potential therapies such as CBD and hemp oils is a promising area for the future of clinical pain management for both pain relief as well as addiction management," Dr. Karen Mauck, an internist at Mayo Clinic, and her co-authors wrote.

Dr. Hance Clarke, director of pain services at Toronto General Hospital who wasn't involved in the U.S. paper, said he starts by asking patients what symptoms they want to use CBD to treat.

It's one of the first times in Canadian history where a medication has made it to the population without the science actually leading us there.- Dr. Hance Clarke, director of pain services at Toronto General Hospital

"The evidence has not caught up to the story that's in the public," Clarke said. "It's tricky. It's one of the first times in Canadian history where a medication has made it to the population without the science actually leading us there."

Physicians need to work with patients to figure out what people are using, the levels in their body and what's actually helped and what hasn't.

"The world is looking to Canada over the next five to 10 years," Clarke said. An evidence-based perspective on cannabis is needed rather than solely industry's, he said.

Canada's Arthritis Society said there's limited clinical evidence so far on the relative benefits and risks of medical cannabis to treat osteoarthritis and rheumatoid arthritis.

CBD now is widely used by people for all kinds of disease, in particular anxiety, panic attack, bipolar disorder, depression. But we don't know if CBD is really good for these kind of diseases.- Dr. Gabriella Gobbi

In January, research into CBD's effects on pain and anxiety in lab rats was published in the scientific journal Pain.

"CBD now is widely used by people for all kinds of disease, in particular anxiety, panic attack, bipolar disorder, depression," said Dr.Gabriella Gobbi, the study's author and a psychiatrist at McGill University's faculty of medicine in Montreal. "But we don't know if CBD is really good for these kinds of diseases."

Only clinical trials in humans can show if CBD is really effective for anillness, Gobbi said.

In Canada, pharmaceutical companies are sponsoring clinical trials to test CBD products in people.

How do you know what's in the product?

Depending on what part of the plant is extracted, different components will be present in the oil, the Mayo Clinic authors said. Their list of what clinicians should look for includes:

• Manufacturing standards certification, such as pesticide or herbicide testing.
• European Union or Australian organic certification.
• Lab testing to confirm cannabinoid levels and the absence of heavy metals.

"We see variations from batch to batch where patients are doing well on something, and potentially the next time they seek that same product, potentially they're not seeing the same effects," Clarke said.

A research letter published in 2017 in JAMAfound nearly 70 per cent of CBD extracts sold online were mislabelled.

"A lot of CBD oil can have very little or contain lots of THC, so you must be very careful," Gobbi said. "We need more quality control."

What side-effects have been reported?

In larger studies on CBD treatment for epileptic patients, it was associated with drowsiness, decreased appetiteand diarrhea in up to 36 per cent of people, the Mayo Clinic authors said, adding the side-effects were less severe and frequentcompared with a conventional anticonvulsant medication.

The FDA said its review of a marketing application forEpidiolex suggested potential for liver injury associated with CBD.

You can't just self-treat.- Dr. Gabriella Gobbi

"You can't just self-treat," Gobbi said.

What about drug interactions?

The main drug interactions doctors and pharmacists look for are drugs, such as morphine, oxycodone, sleeping pills, antidepressants or antipsychotics, that already make you sleepy, confused or impair co-ordination.

"If you're taking those medications to begin with and you use cannabis, we'd expect that those side effects would get worse," said Kelly Grindrod of the University of Waterloo's School of Pharmacy.

People should talk to their physician, nurse or pharmacist to discusspotential drug interactions when determining whether to try CBD.

Maddie Brown, a registered practical nurse and cannabis consultant based in Ottawa, helps patients with medical cannabis prescriptionsunderstand how CBD works and obtain it.

"I'm definitely most concerned about blood thinners," Brown told CBC Radio's White Coat, Black Art. "CBD can make Coumadin [a blood thinning medication] more potent."

The general advice is to start low and go slow, especially if takingmedications that are known to interact, Grindrod said.