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Zika virus: new ways to fight mosquitoes needed after dengue failure, WHO says

The World Health Organization says that the traditional insecticide spraying methods have had no significant impact in slowing dengue, raising significant questions about how officials might stop the spread of the Zika virus, also spread by mosquitoes.

'Evidence is missing' that classical ways of fighting dengue reduced cases

Zika labs busy

9 years ago
Duration 1:42
Virus outbreak could be long over by the time scientists come up with a vaccine
The World Health Organization says that traditionalinsecticide spraying has had no significant impact in slowingdengue, raising major questions about how officials might stop thespread of the Zika virus, also spread by mosquitoes.

At the conclusion of a three-day Zika research and developmentmeeting on Wednesday, WHO's Marie-Paule Kieny said that "evidenceis missing" that the classical ways of fighting dengue have madeany substantial dent in cases. She says the same challenge mightapply to Zika.

"Everything that was done in the country to control [mosquitoes]apparently didn't work," said Jorge Kalil, director of the ButantanInstitute in Sao Paolo, Brazil, who attended the meeting.

"Theproblem right now is it's very difficult to fight the [mosquito],there are billions and billions of insects."

Kalil said Brazilian officials may try a more targeted approachcalling for more involvement from villages and individuals. Kalilwas also optimistic that the coming winter season might help reducemosquito populations.

Kieny said insecticide spraying and other techniques of mosquitocontrol some that have been used for decades"haven't been ableto interrupt the transmission of dengue," and it's not knownwhether such methods would work with Zika.

"Certainly it is worth continuing to try to use this method forthe lack of other interventions, but what the scientists said isthat there is an urgent need to also put in place studies toevaluate whether it has a benefit or not," Kieny said.

Brazilian authorities have tried to fight mosquitoes for decades,such as with techniques like deploying insecticide-sprayers incoloured suits in rural areas or sending out advisers to help cityresidents identify and root out their breeding places in homes.

Kieny also noted another possible complication: that othermosquito species beyond Aedes aegypti might spread Zika. She saidthat while scientists have observed that other mosquito species cancarry the virus, it's unclear if they can actually infect people.

Kieny said experts at the meeting discussed whether innovativemethods like using genetically modified mosquitoes might benecessary to stop the outbreak, but noted that "extreme rigour"must be used in evaluating such new tools.

Last month, WHO declared the explosive spread of Zika in theAmericas to be a global emergency, due to its link to the spike inthe number of babies born with abnormally small heads and the risein a rare neurological syndrome that can cause paralysis and death.

Most people who catch Zika only experience mild symptoms like fever,skin rash and muscle pain. There is currently no licensed treatmentor vaccine.

So far, Zika has triggered outbreaks in 41 countries, althoughconfirmed cases linking Zika to babies with birth defects have onlybeen seen in Brazil and French Polynesia. Nine countries havereported a spike in cases of Guillain-Barre syndrome, a neurologicalcondition that typically affects people after infections.

Kieny said vaccine development is still at an early stage andthat although the most advanced candidates are still months awayfrom preliminary trials, a Zika vaccine is "technologicallyfeasible" based on the development of other vaccines for relateddiseases like dengue and Japanese encephalitis.

She said work is being done by more than 30 companies to developa better diagnostic Zika test, since current tests often mix up Zikaand dengue infections.