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Hamilton

McMaster scientists discover cancer-killing drug

Researchers say the drug thioridazine kills cancer stem cells while having no effect on normal stem cells.

It's a new drug that kills cancer stems cells without the grueling side effects of conventional cancer treatments.

McMaster researchers are hopeful patients with leukemia and breast cancerwill benefit from this discovery.

The drug, thioridazine, is unlike chemotherapy and radiation in that it seems to have no effect on normal stem cells. What's even better, McMaster University Dr. Mick Bhatia says, is that health issues associated with traditional cancer treatments such as hair loss, nausea and aseverely weakenedimmune system, seem to be eliminated with this drug.

"There are very few drugs that are very specific to cancer stem cells," Bhatia explained. "It's relatively novel. It's a significant advancement."

Bhatia says thioridazine is currently being usedon Parkinson's and schizophrenia patients. He believes human clinical trials will move swiftly because of its use withthese diseases.

Clinical trials will first focus on patients with acute myeloid leukemia whose disease has relapsed after chemotherapy.

"It's a very small group of people," Bhatia said, but he is hopeful this is just the beginning of a real breakthrough in cancer treatment.