HOUSTON (AP) The Houston Astros have placed second baseman Jose Altuve, third baseman Alex Bregman, designated hitter Yordan lvarez, catcher Martn Maldonado and infielder Robel Garcia on the injured list because of COVID-19 health and safety protocols.

General manager James Click made the announcement on Wednesday, hours before the Astros were to wrap up a three-game series with the Detroit Tigers.

Click said he couldnt say if a player had tested positive for COVID-19 or been exposed to someone who had and that the length of each players absence would be determined by contract testing that is being performed.

Click was asked if the situation could have caused the game to be postponed.

Weve been in close contact with Major League Baseball throughout the day about that possibility, he said. They dont believe that there is a health-safety reason not to play. So as of now, we are playing the game.

To take their place, infielders Taylor Jones, Abraham Toro and Alex De Goti, outfielder Ronnie Dawson and catcher Garrett Stubbs have been recalled from the alternate training site.

The Astros have lost four games in a row after a 6-1 start and now must play without four members of their starting lineup.

Its just a challenge for the rest of our guys to pick us up and and get us back on the right track, Click said. Weve obviously (struggled) a little bit in the past past four games. When it rains, it pours. Its a difficult situation but we cant let that take our focus away from from winning this game.