Everyone loves baby giggles, and the Mathias quadruplets are proof of that.

In the early 2000s, a video of the four infants lying on their mother and giggling adorably in unison became a prize-winning clip on Americas Funniest Home Videos. A few years later, the show declared the laughing quadruplets video to be the Funniest Video of All-Time, earning the Mathias family $250,000 and a place in home-video history.

The girls Grace, Emily, Mary Claire and Anna were 6 years when their video took that top honor, and the Mathias family made multiple television and talk-show appearances in the years to follow, including a stop by The Oprah Winfrey Show in 2008.