Actor Matthew Perry, who was found dead at age 54 at his Los Angeles home in October, died from the acute effects of ketamine, according to a Friday news release from the Los Angeles County Medical Examiner.

Contributing factors in Perrys accidental death included drowning, coronary artery disease and the effects of buprenorphine, a drug used in the treatment of opioid addiction.

Ketamine is an anesthetic drug that is sometimes used in treatments for depression and other mental health conditions. Some people also use it recreationally for its hallucinogenic and dissociative effects.

An autopsy report noted that Perry had previously been on ketamine infusion therapy. However, the report said his last therapy session had occurred a week and a half before his death, so the ketamine found in his system could not have been from that treatment.

The high levels of ketamine in Perrys body would have caused cardiovascular overstimulation and respiratory depression, the report said.

Law enforcement found Perry dead in his hot tub on the afternoon of Oct. 28. At the time, it appeared to be a drowning incident.

Perry, who starred as Chandler Bing in the smash 90s sitcom Friends, publicly dealt with substance abuse issues, which he described in a 2022 memoir. In 2013, he founded the Perry House, a mens sober living facility, in Malibu, California.